complement factor c7 contributes to lung immunopathology caused by mycobacterium tuberculosisc7补充因素导致肺癌免疫病理由结核分枝杆菌引起的.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 429675, 7 pages doi:10.1155/2012/429675 Research Article Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis Kerry J. Welsh,1 Cole T. Lewis,1 Sydney Boyd,1 Michael C. Braun,2 and Jeffrey K. Actor1 1 Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA 2 Department of Pediatrics-Renal Section, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030, USA Correspondence should be addressed to Jeffrey K. Actor, jeffrey.k.actor@ Received 11 May 2012; Accepted 20 July 2012 Academic Editor: Daniel Rittirsch Copyright © 2012 Kerry J. Welsh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mycobacterium tuberculosis (MTB) remains a significant global health burden despite the availability of antimicrobial chemother- apy. Increasing evidence indicates a critical role of the complement system in the development of host protection against the bacillus, but few studies have specifically explored the function of the terminal complement factors. Mice deficient in complement C7 and wild-type C57BL/6 mice were aerosol challenged with MTB Erdman and assessed for bacterial burden, histopathology, and lung cytokine responses at days 30 and 60 post-infection. Macrophages isolated from C7 −/− and wild-type mice were evaluated for MTB proliferation and cytokine production. C7 −/− mice had significantly less liver colony forming units (CFUs) at day 30; no differences were noted in lung CFUs. The C7 deficient mice had markedly redu