body weight control by a high-carbohydratelow-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model体重控制饮食high-carbohydratelow-fat减缓糖尿病肾脏损害的发展在一个肥胖,高血压、2型糖尿病大鼠模型.pdfVIP

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body weight control by a high-carbohydratelow-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model体重控制饮食high-carbohydratelow-fat减缓糖尿病肾脏损害的发展在一个肥胖,高血压、2型糖尿病大鼠模型.pdf

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body weight control by a high-carbohydratelow-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model体重控制饮食high-carbohydratelow-fat减缓糖尿病肾脏损害的发展在一个肥胖,高血压、2型糖尿病大鼠模型

Hindawi Publishing Corporation Journal of Obesity Volume 2010, Article ID 136502, 11 pages doi:10.1155/2010/136502 Research Article Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model Shuichi Ohtomo,1, 2 Yuko Izuhara,2 Masaomi Nangaku,3 Takashi Dan,4 Sadayoshi Ito,5 Charles van Ypersele de Strihou,6 and Toshio Miyata4 1 Research Division, Chugai Pharmaceutical Co., LTD., Shizuoka 412-8513, Japan 2 Institute of Medical Sciences, Tokai University, Kanagawa 259-1193, Japan 3 Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo 113-8655, Japan 4 Center for Translational and Advanced Research, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan 5 Department of Nephrology, Hypertension and Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan 6 Service de Nephrologie, Universite Catholique de Louvain, 1200 Brussels, Belgium Correspondence should be addressed to Shuichi Ohtomo, ohtomosui@chugai-pharm.co.jp Received 11 June 2009; Revised 7 October 2009; Accepted 16 November 2009 Academic Editor: Terry Huang Copyright © 2010 Shuichi Ohtomo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high- carbohydrate/low-fat diet (HC/LF group). Daily caloric