chitosan nanoparticles as a percutaneous drug delivery system for hydrocortisone壳聚糖纳米粒子作为氢化可的松的经皮给药系统.pdfVIP

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2012, Article ID 372725, 11 pages doi:10.1155/2012/372725 Research Article Chitosan Nanoparticles as a Percutaneous Drug Delivery System for Hydrocortisone Haliza Katas, Zahid Hussain, and Tay Chai Ling Drug Delivery and Novel Targeting Research Group, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia Correspondence should be addressed to Haliza Katas, haliz12@ Received 9 February 2012; Revised 23 March 2012; Accepted 26 March 2012 Academic Editor: Zhongkui Hong Copyright © 2012 Haliza Katas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hydrocortisone (HC) has formed the mainstay for the management of atopic dermatitis. Hence, HC-loaded chitosan nanoparticles were prepared by ionic crosslinking of high, low molecular weight chitosan (HMwt, LMwt CS) and N-trimethyl chitosan (TMC) with tripolyphosphate. HC loading into CS nanoparticles was confirmed by FT-IR. The particle size of HC-loaded HMwt, LMwt, and TMC nanoparticles was increased from 243 ±12, 147±11, and 124±9 nm to 337 ±13, 222±14, and 195±7 nm, respectively, by increasing the pH of CS solution. Their respective zeta potential and entrapment efficiency (EE) were significantly decreased by increasing the pH of CS solution. The swelling ratios of HC loaded HMwt, LMwt, and TMC NPs were increased when the pH of incubating media (PBS) was increased. The same increasing trend was observed in particle size and EE of HC loaded as the CS concentration was increased. The HC loaded CS NPs were generally nonspherica