computational fluid dynamics analysis of the effect of plaques in the left coronary artery计算流体动力学分析,在左冠状动脉斑块的影响.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 504367, 9 pages doi:10.1155/2012/504367 Research Article Computational Fluid Dynamics Analysis of the Effect of Plaques in the Left Coronary Artery Thanapong Chaichana,1 Zhonghua Sun,1 and James Jewkes2 1 Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, GPO Box, U1987, Perth, WA 6845, Australia 2 Fluid Dynamics Research Group, Department of Mechanical Engineering, Curtin University, Perth, WA 6845, Australia Correspondence should be addressed to Zhonghua Sun, z.sun@.au Received 30 September 2011; Revised 8 November 2011; Accepted 9 November 2011 Academic Editor: Kyehan Rhee Copyright © 2012 Thanapong Chaichana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study was to investigate the hemodynamic effect of simulated plaques in left coronary artery models, which were generated from a sample patient’s data. Plaques were simulated and placed at the left main stem and the left anterior descending (LAD) to produce at least 60% coronary stenosis. Computational fluid dynamics analysis was performed to simulate realistic physiological conditions that reflect the in vivo cardiac hemodynamics, and comparison of wall shear stress (WSS) between Newtonian and non- Newtonian fluid models was performed. The pressure gradient (PSG) and flow velocities in the left coronary artery were measured and compared in the left coronary models with and without presence of plaques during cardiac cycle. Our results showed that the highest PSG was observed in stenotic