genetic background strongly influences the bone phenotype of p2x7 receptor knockout mice遗传背景强烈影响骨p2x7受体基因敲除小鼠的表型.pdfVIP

Hindawi Publishing Corporation Journal of Osteoporosis Volume 2012, Article ID 391097, 9 pages doi:10.1155/2012/391097 Research Article Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice Susanne Syberg,1, 2 Solveig Petersen,1 Jens-Erik Beck Jensen,2 Alison Gartland,3 Jenni Teilmann,2 Iain Chessell,4 Thomas H. Steinberg,5 Peter Schwarz,1, 6 and Niklas Rye Jørgensen1, 2 1 Departments of Diagnostics and Medicine, Research Centre of Ageing and Osteoporosis, Glostrup University Hospital, 2600 Glostrup, Denmark 2 Osteoporosis and Bone Metabolic Unit, Departments of Endocrinology and Clinical Biochemistry, Hvidovre University Hospital, 2650 Hvidovre, Denmark 3 Mellanby Centre for Bone Research, The University of Sheffi eld, Sheffi eld S10 2TN, UK 4 NeuroScience and MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK 5 Department of Internal Medicine, Washington University School of Medicine and St. Louis Veterans Aff airs Medical Center, St. Louis, MO 63106, USA 6 Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark Correspondence should be addressed to Susanne Syberg, syberg@ruc.dk Received 31 March 2012; Revised 28 June 2012; Accepted 2 July 2012 Academic Editor: Elena Adinolfi Copyright © 2012 Susanne Syberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The purinergic P2X7 receptor is expressed by bone cells and has been shown to be important in both bone formation and bone resorption. In this study we investigated the importance of the genetic background of the mouse s