fibronectin in immune responses in organ transplant recipients纤连蛋白在器官移植受者的免疫反应.pdfVIP

Developmental Immunology, 2000, Vol. 7(2-4), pp. 239-248 (C) 2000 OPA (OverseasPublishers Association) Reprints available directly from the publisher N.V. Published by license under the Photocopying permitted by license only Harwood Academic Publishers imprint, part of the Gordon and Breach Publishing Group. Printed in Malaysia Fibronectin in Immune Responses in Organ Transplant Recipients ANA J. COITOa*, MARIA DE SOUSAb and JERZY W. KUPIEC-WEGLINSKIa aThe Dumont-UCLA Transplant Center, Division ofLiver and Pancreas Transplantation, Department ofSurgery, UCLA School ofMedicine, Los Angeles, CA 90095, USA and bThe Abel Salazar Institute for Biomedical Sciences, 4000 Porto, Portugal The immune response to an organ allograft involves perpetuation of T cell infiltration and activation. Advances in understanding the mechanisms of T cell activation have placed par- ticular emphasis on the interactions between the T-cell receptor and antigen presenting cells, with little reference to the fact that in vivo activation occurs in the physical context of extra- cellular matrix proteins (ECM). Indeed, the possibility that ECM proteins may have a deter- mining role in lymphocyte adhesion and tissue localization and function is now becoming more appreciated in view of growing evidence indicating that integrins and other T cell an