effects of thalidomide on the expression of adhesion molecules in rat liver cirrhosis萨力多胺对大鼠肝硬化的粘附分子的表达.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2006, Article ID 93253, Pages 1– 10 DOI 10.1155/MI/2006/93253 Research Communication Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis Peng Lv, Shelley Chireyath Paul, Yanjv Xiao, Shiquan Liu, and Hesheng Luo Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China Received 15 December 2005; Accepted 13 March 2006 This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was in- duced in Wistar rats by intraperitoneal injection of CCl4 , and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragas- tric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-α mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-α mRNA and that of ICAM-1, VCAM-1, and E- selectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis. Copyright © 2006 Peng Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION disease severity according to the Child-Pugh classification [14]. Adhesion molecules are proteins expressed on a variety of cells, which mediate the interaction between endothel