development and congenital anomalies of the pancreas发展和胰腺的先天性畸形.pdfVIP

Hindawi Publishing Corporation Anatomy Research International Volume 2011, Article ID 351217, 7 pages doi:10.1155/2011/351217 Review Article Development and Congenital Anomalies of the Pancreas Hiroyuki Tadokoro,1 Masaru Takase,2 and Bunsei Nobukawa2 1 Department of Gastroenterology, Asakadai Central Hospital, 1-8-10 Nishibenzai, Asaka, Saitama 351-2055, Japan 2 Department of Human Pathology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Correspondence should be addressed to Hiroyuki Tadokoro, heroyou27@yahoo.co.jp Received 16 December 2010; Accepted 28 February 2011 Academic Editor: Farzad Esni Copyright © 2011 Hiroyuki Tadokoro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Understanding how the pancreas develops is essential to understand the pathogenesis of congenital pancreatic anomalies. Recent studies have shown the advantages of investigating the development of frogs, mice, and chickens for understanding early embryonic development of the pancreas and congenital anomalies, such as choledochal cysts, anomalous pancreaticobiliary junction, annular pancreas, and pancreas divisum. These anomalies arise from failure of complete rotation and fusion during embryogenesis. There are many theories in the etiology of congenital anomalies of the pancreas. We review pancreas development in humans and other vertebrates. In addition, we attempt to clarify how developmental failure is related to congenital pancreatic anomalies. 1. Introduction choledochal cysts, because 90% of cysts are complicated