disrupting ovarian cancer metastatic colonization insights from metastasis suppressor studies扰乱卵巢癌转移转移抑制基因研究殖民见解.pdfVIP

Hindawi Publishing Corporation Journal of Oncology Volume 2010, Article ID 286925, 7 pages doi:10.1155/2010/286925 Review Article Disrupting Ovarian Cancer Metastatic Colonization: Insights from Metastasis Suppressor Studies Shaheena Khan,1 Jennifer L. Taylor,2 and Carrie W. Rinker-Schaeffer1, 2, 3 1 Section of Urology, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA 2 Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA 3 Urology Research, The Departments of Surgery, Obstetrics and Gynecology, and Medicine, The University of Chicago, Chicago, IL 60637, USA Correspondence should be addressed to Carrie W. Rinker-Schaeffer, crinkers@ Received 5 August 2009; Accepted 6 December 2009 Academic Editor: Maurie M. Markman Copyright © 2010 Shaheena Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ovarian cancer affects approximately 25,000 women in the United States each year and remains one of the most lethal female malignancies. A standard approach to therapy is surgical cytoreduction, after which the remaining microscopic residual disease is treated with chemotherapy. The vast majority of patients have disease recurrence, underscoring the crucial need for approaches to control the regrowth, or colonization, of tissues after local treatment. Improved therapies require mechanistic information about the process of metastatic colonization, the final step in metastasis, in which cancer cells undergo progressive growth at secondary sites. Studies of metastasis suppressors are providing insights into ev