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biological effects of ev71 infection in neural cellsev71感染神经细胞的生物学效应.pdf

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biological effects of ev71 infection in neural cellsev71感染神经细胞的生物学效应

Vol.1, No.2, 113-118 (2010) Journal of Biophysical Chemistry doi:10.4236/jbpc.2010.12014 * Biological effects of EV71 infection in neural cells 1# 2# 2 2 2 2** Xia Cao , Li-Chun Wang , Long-Ding Liu , Yun Liao , Cheng-Hong Dong , Qi-Han Li 1 # Department of Immunology and Microbiology, Kunming Medical College, Kunming, China; Both authors contributed equally to this work 2Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China; **Corresponding Author: imbcams.lq@ Received 23 May 2010; revised 25 June 2010; accepted 30 June 2010. ABSTRACT great importance. A number of studies have reported the development of a mouse-adapted HEV71 strain and new- Enterovirus 71 (EV71) can cause serious nerv- born mice infected with mouse-adapted HEV71 [8-10]. ous system lesions but to date the pathogene- These evidence suggests that rodents are not resistant to sis has been unclear. Our results show that EV71 infection. Etiological studies of EV71 have so far EV71 proliferates in the neural cells and leads to