characterizing t cells in scid patients presenting with reactive or residual t lymphocytes描述在scid患者t细胞反应性或残余t淋巴细胞.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 261470, 9 pages doi:10.1155/2012/261470 Research Article Characterizing T Cells in SCID Patients Presenting with Reactive or Residual T Lymphocytes Atar Lev,1, 2 Amos J. Simon,1 Luba Trakhtenbrot,1, 3 Itamar Goldstein,1, 3 Meital Nagar,1, 3 Polina Stepensky,4 Gideon Rechavi,1 Ninette Amariglio,1, 3 and Raz Somech1, 2 1 Cancer Research Center, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel 2 Hematology Laboratory, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel 3 Pediatric Immunology Service of Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel 4 Department of Pediatric Hematology-Oncology, Hadassah Medical Center, Hadassah Hebrew University, 91120 Jerusalem, Israel Correspondence should be addressed to Raz Somech, raz.somech@.il Received 13 June 2012; Revised 29 July 2012; Accepted 5 August 2012 Academic Editor: George N. Goulielmos Copyright © 2012 Atar Lev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Patients with severe combined immunodeficiency (SCID) may present with residual circulating T cells. While all cells are functionally deficient, resulting in high susceptibility to infections, only some of these cells are causing autoimmune symptoms. Methods. Here we compared T-cell functions including the number of circulating CD3+ T cells, in vitro responses to mitogens, T- cell receptor (TCR) r