covariation of mutation pairs expressed in hiv-1 protease and reverse transcriptase genes subjected to varying treatments共变的突变对hiv - 1蛋白酶和逆转录酶基因表达受到不同的治疗方法.pdfVIP

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covariation of mutation pairs expressed in hiv-1 protease and reverse transcriptase genes subjected to varying treatments共变的突变对hiv - 1蛋白酶和逆转录酶基因表达受到不同的治疗方法.pdf

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covariation of mutation pairs expressed in hiv-1 protease and reverse transcriptase genes subjected to varying treatments共变的突变对hiv - 1蛋白酶和逆转录酶基因表达受到不同的治疗方法

J. Biomedical Science and Engineering, 2010, 3, 291-299 JBiSE doi:10.4236/jbise.2010.33039 Published Online March 2010 (http://www.SciRP.org/journal/jbise/). Covariation of mutation pairs expressed in HIV-1 protease and reverse transcriptase genes subjected to varying treatments * David King, Roger Cherry, Wei Hu Department of Computer Science, Houghton College, Houghton, USA. Email: wei.hu@. Received 7 October 2009; revised 27 November 2009; accepted 4 December 2009. ABSTRACT In particular, the study of correlation, or covariation, between mutations has been a focus. A particularly strong A previous study, focused on the correlation of muta- correlation between amino acids can be seen as evidence tion pairs of synonymous (S) and asynonymous (A) of a functional link between those amino acids. Studying mutations, distinguished only between the treated the covariation of these mutations will help both our and untreated data of protease and reverse tran- understanding of the HIV-1 virus, and our ability to treat it. scriptase (RT) of HIV-1 subtype B. It is well known There is more than one type of mutation which HIV that single mutation patterns in HIV-1 are treat- undergoes. However,