balance between pro- and anti-inflammatory cytokines in mice treated with centruroides noxius scorpion venom赞成和小鼠抗炎细胞因子之间的平衡处理centruroides noxius蝎子毒液.pdfVIP

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balance between pro- and anti-inflammatory cytokines in mice treated with centruroides noxius scorpion venom赞成和小鼠抗炎细胞因子之间的平衡处理centruroides noxius蝎子毒液.pdf

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balance between pro- and anti-inflammatory cytokines in mice treated with centruroides noxius scorpion venom赞成和小鼠抗炎细胞因子之间的平衡处理centruroides noxius蝎子毒液

Hindawi Publishing Corporation Mediators of Inﬂammation Volume 2006, Article ID 54273, Pages 1– 11 DOI 10.1155/MI/2006/54273 Research Communication Balance Between Pro- and Anti-Inﬂammatory Cytokines in Mice Treated With Centruroides noxius Scorpion Venom Vera L. Petricevich Laboratorio de Toxicologıa, Facultad de Medicina de la Universidad Autonoma del Estado de Morelos, 62210 Cuernavaca, Mexico ´ ´ Received 21 June 2006; Revised 10 September 2006; Accepted 11 September 2006 CSV consists of a very complex of molecules and demonstrates signiﬁcant cellular activities capable of stimulating immune func- tions in vivo. The purpose of this study was to analyze the eﬀects of CSV on sex, weight, route of injection and the balance of pro- and anti-inﬂammatory cytokines in mice. The susceptibility and route of injection were analyzed by lethal (LD50 ) determination. The eﬀects of CSV were also analyzed in blood from immunized mice using detection by means of antibodies and mediators pro- duction. Several functional bioassays were employed: TNF activity was assayed by measuring its cytotoxic activity in L929 cells, and other cytokines were assayed by enzyme-linked immunosorbent assay, whereas nitric oxide levels were detected by Griess colori- metric reactions in sera from BALB/c mice. After injecting subcutaneously, the LD50 presented an increase of the CSV correlation and similar levels of susceptibility were obtained for female and male from BALB/c mice. Signiﬁcant diﬀerences were observed in the time-course of cytokine levels. The balance of pro- and anti-inﬂammatory cytokines TNF/IL-10 and IL-6/IL-10 ratios were signiﬁcantly higher in injected mice group when compared with those obtained for non-injected group. The CSV is po