bartonella infection in immunocompromised hosts immunology of vascular infection and vasoproliferation巴尔通氏体属感染免疫力低下宿主血管感染的免疫学和vasoproliferation.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 612809, 5 pages doi:10.1155/2012/612809 Review Article Bartonella Infection in Immunocompromised Hosts: Immunology of Vascular Infection and Vasoproliferation Mosepele Mosepele, Dana Mazo, and Jennifer Cohn Department of Medicine, Hospital of the University of Pennsylvania, 100 Centrex, Philadelphia, PA 19104, USA Correspondence should be addressed to Mosepele Mosepele, mosepele.mosepele@ Received 15 July 2011; Revised 27 September 2011; Accepted 29 September 2011 Academic Editor: Georgios Pappas Copyright © 2012 Mosepele Mosepele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Most infections by genus Bartonella in immunocompromised patients are caused by B. henselae and B. quintana. Unlike immunocompetent hosts who usually develop milder diseases such as cat scratch disease and trench fever, immunocompromised patients, including those living with HIV/AIDS and posttransplant patients, are more likely to develop different and severe life- threatening disease. This paper will discuss Bartonella’s manifestations in immunosuppressed patients and will examine Bartonella’s interaction with the immune system including its mechanisms of establishing infection and immune escape. Gaps in current understanding of the immunology of Bartonella infection in immunocompromised hosts will be highlighted. 1. Introduction reservoir for both B. quintana and B. bacilliformis have not yet been ide