beneficial effect of reduced oxygen concentration with transfer of blastocysts in ivf patients older than 40 years old有益的影响降低氧浓度与体外受精胚泡转移患者年龄超过40岁.pdfVIP

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beneficial effect of reduced oxygen concentration with transfer of blastocysts in ivf patients older than 40 years old有益的影响降低氧浓度与体外受精胚泡转移患者年龄超过40岁.pdf

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beneficial effect of reduced oxygen concentration with transfer of blastocysts in ivf patients older than 40 years old有益的影响降低氧浓度与体外受精胚泡转移患者年龄超过40岁

Vol.2, No.9, 1010-1017 (2010) Health doi:10.4236/health.2010.29149 Beneficial effect of reduced oxygen concentration with transfer of blastocysts in IVF patients older than 40 years old Javier I. García*, Soledad Sepúlveda, Luis Noriega-Hoces Laboratory of Assisted Reproduction, Concebir Clinic, Lima, Peru; *Corresponding Author: jgarciaf@ Received 6 February 2010; revised 1 March 2010; accepted 5 March 2010. ABSTRACT ranging from 2 to 8% observed in atmospheric air [1-3]. This probably corresponds to an adaptation mechanism, The aim of the present study was to determine as it is proven that higher oxygen concentrations may be the impact of oxygen concentration on implan- harmful to the embryo [4] by generating reactive oxygen tation, pregnancy and delivery rates in IVF pa- species (ROS) [5-7]. tients older than 40 year old with transfer of In Vitro fertilization studies (IVF) in mice [8,9]; cattle blastocysts. Included were 558 women aged [5]; sheep [10]; rabbits [11]; hamsters [12]; rats [13]; 23-45 years old undergoing IVF/ICSI procedures cows [14] and pigs [15] have demonstrated that when whose embryos were cultured at blastocyst cultured in oxygen concentrations of 5% present a higher stage under two different oxygen environments viability and a better development to the blastocyst stage. (a bi-gas system: 5.6% CO2 in air and a tri-gas However, a pioneer study in human embryos showed system: 5.6% CO , 5% de O and 89.4% N ). The 2