bone loss rate may interact with other risk factors for fractures among elderly women a 15-year population-based study骨质疏松骨折率可能与其他风险因素在老年女性15年以人群为基础的研究.pdfVIP

SAGE-Hindawi Access to Research Journal of Osteoporosis Volume 2010, Article ID 736391, 10 pages doi:10.4061/2010/736391 Research Article Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study Joonas Sirola,1, 2 Anna-Kaisa Koistinen,1 Kari Salovaara,1, 2 Toni Rikkonen,1 Marjo Tuppurainen,1, 3 Jukka S. Jurvelin,4 Risto Honkanen,1 Esko Alhava,5 ¨ 1, 2 and Heikki Kroger 1 Bone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, Finland 2 Department of Orthopedics and Traumatology, Kuopio University Hospital, 70211 Kuopio, Finland 3 Department of Obstetrics and Gynaecology, Kuopio University Hospital, 70211 Kuopio, Finland 4 Department of Clinical Physiology Nuclear Medicine, Kuopio University Hospital, 70211 Kuopio, Finland 5 Department of Surgery, Kuopio University Hospital, 70211 Kuopio, Finland Correspondence should be addressed to Joonas Sirola, joonas.sirola@kuh.fi Received 8 September 2009; Revised 15 November 2009; Accepted 31 December 2009 Academic Editor: Saeko Fujiwara Copyright © 2010 Joonas Sirola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high 0.84%, moderate 0.13%–0.84%, and low 0.13%. Low trauma energy fractures during following 10 years were recorded. There were no differences in FR between BL tertiles in Cox r