burkholderia cepacia complex emerging multihost pathogens equipped with a wide range of virulence factors and determinants伯克不过复杂的新兴multihost病原体配备多种毒力因子和决定因素.pdfVIP

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burkholderia cepacia complex emerging multihost pathogens equipped with a wide range of virulence factors and determinants伯克不过复杂的新兴multihost病原体配备多种毒力因子和决定因素.pdf

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burkholderia cepacia complex emerging multihost pathogens equipped with a wide range of virulence factors and determinants伯克不过复杂的新兴multihost病原体配备多种毒力因子和决定因素

Hindawi Publishing Corporation International Journal of Microbiology Volume 2011, Article ID 607575, 9 pages doi:10.1155/2011/607575 Review Article Burkholderia cepacia Complex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants ´ ˜ Sılvia A. Sousa, Christian G. Ramos, and Jorge H. Leitao IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal ´ ˜ Correspondence should be addressed to Jorge H. Leitao, jorgeleitao@ist.utl.pt Received 11 May 2010; Accepted 2 June 2010 Academic Editor: Max Teplitski ´ Copyright © 2011 Sılvia A. Sousa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Burkholderia cepacia complex (Bcc) comprises at least 17 closely-related species of the β -proteobacteria subdivision, widely distributed in natural and man-made inhabitats. Bcc bacteria are endowed with an extraordinary metabolic diversity and emerged in the 1980s as life-threatening and diﬃcult-to-treat pathogens among patients suﬀering from cystic ﬁbrosis. More recently, these bacteria became recognized as a threat to hospitalized patients suﬀering from other diseases, in particular oncological patients. In the present paper, we review these and other traits of Bcc bacteria, as well as some of the strategies used to identify and validate the virulence factors a