calcium signalling and liver regeneration钙信号和肝脏再生.pdfVIP

Hindawi Publishing Corporation International Journal of Hepatology Volume 2012, Article ID 630670, 6 pages doi:10.1155/2012/630670 Review Article Calcium Signalling and Liver Regeneration Isabelle Garcin1, 2 and Thierry Tordjmann1, 2 1 INSERM U.757, Universite Paris Sud, Bat. 443, 91405 Orsay, France ´ ˆ 2 Universite Paris Sud, Bat. 443, 91405 Orsay, France ´ ˆ Correspondence should be addressed to Thierry Tordjmann, thierry.tordjmann@u-psud.fr Received 29 June 2012; Accepted 12 September 2012 Academic Editor: Chantal Desdouets Copyright © 2012 I. Garcin and T. Tordjmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. After partial hepatectomy (PH) the initial mass of the organ is restored through a complex network of cellular interactions that orchestrate both proliferative and hepatoprotective signalling cascades. Among agonists involved in this network many of them drive Ca2+ movements. During liver regeneration in the rat, hepatocyte cytosolic Ca2+ signalling has been shown on the one hand to be deeply remodelled and on the other hand to enhance progression of hepatocytes through the cell cycle. Mechanisms through which cytosolic Ca2+ signals impact on hepatocyte cell cycle early after PH are not completely understood, but at least they include regulation of immediate early gene transcription and ERK and CREB phosphorylation. In addition to cytosolic Ca2+ , there is also evidence that mitochondrial Ca2+ and also nuclear Ca2+ may be critical for the regulation of liver regeneration. Finally, Ca2+ move-