原创力文档calculating summary measures of unimodal response curves by means of nonlinear regression models计算总结措施单峰响应曲线的非线性回归模型.pdfVIP
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calculating summary measures of unimodal response curves by means of nonlinear regression models计算总结措施单峰响应曲线的非线性回归模型
Joumii/ of Tlieoreiiciil Mriiii,inu, Vol. 2. pp 73-80 % 2000 OIA iOiesiees Pubh\hsrs Asiociat~un)N V
Reprints a\ailahls durctly kum the publisher Publnhed by llccnie under
Photocopyng perinitled by I~czmconl? the Gordon and Brcach Science
Publ~\herrimprint.
Pr~ntedin Malaysia
Calculating Summary Measures of Unimodal Response
Curves by Means of Nonlinear Regression Models
RALF BENDER*
Departnzertt ofMefnholic I3iseirse.r arid Nutrition, Heinrich-Heirle-UiliveerihofDDii.rseldoi$ P.O. Box 10 10 07, 0-40001 Dcisseldorj;
Germany
(Rececved 10March 1998, I n /~nnlforri~8 Januun 1999)
In biomedical research summary measures such as the curve maximum (C,,,,,)are
frequently used to describe and analyze unimodal response curves. However, if the true
curve is perturbed by autocorrelated noise the calculation of summary measures from
raw data can be arbitrary and misleading due to high peaks produced by the correlated
errors. A possible solution is to fit suitable nonlinear functions to the response curves and
estimate the summary measures from these functions. In this paper formulas are derived
providing a
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