cag and ggn repeat length polymorphisms of androgen receptor gene in women with breast cancer a case-control study from south india的雄激素受体基因cag和ggn重复长度多态性在患有乳腺癌的妇女从印度南部一个病例对照研究.pdfVIP

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cag and ggn repeat length polymorphisms of androgen receptor gene in women with breast cancer a case-control study from south india的雄激素受体基因cag和ggn重复长度多态性在患有乳腺癌的妇女从印度南部一个病例对照研究.pdf

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cag and ggn repeat length polymorphisms of androgen receptor gene in women with breast cancer a case-control study from south india的雄激素受体基因cag和ggn重复长度多态性在患有乳腺癌的妇女从印度南部一个病例对照研究

Journal of Cancer Therapy, 2012, 3, 741-748 741 /10.4236/jct.2012.325093 Published Online October 2012 (http://www.SciRP.org/journal/jct) CAG and GGN Repeat Length Polymorphisms of Androgen Receptor Gene in Women with Breast Cancer: A Case-Control Study from South India 1 1 2 1 2 Durgadatta Tosh , Bineet Panda , Tipirisetti Nageswar Rao , Arvind Babu , Vishnupriya Satti , Digumarti Raghnadharao3 1 1* , Lalji Singh , Lakshmi Rao 1Centre for Cellular and Molecular Biology, Hyderabad, India; 2Department of Genetics, Osmania University, Hyderabad, India; 3Department of Medical Oncology, Nizams Institute of Medical Sciences, Hyderabad, India. * Email: lakshmi@ccmb.res.in Received April 17th, 2012; revised May 22th, 2012; accepted June 13th, 2012 ABSTRACT Aim: The Androgen Receptor (AR) is a ligand-dependent transcriptional activator and the AR gene contains a highly polymorphic trinucleotide repeat CAG and GGN in the first exon. Given the lack of information AR-CAG and GGN repeat polymorphism and its potential correlation with breast cancer in South Indian women, we conducted a case-con- trol study to observe the effects of CAG GGN repeat length polymorphism and risk of breast cancer. Methods: Polymorphisms for AR-CAG and GGN repeat length was detected by Gene Scan analysis in the genomic DNA from cases with breast cancer and controls. Results: Association between AR genotype was calculated by categorising alleles as short (S) and long (L) and taking median value as the cut-off. LL genotype of CAG repeat was found to be associated with breast cancer (OR, 4.58; 95% CI, 10.61 - 1.98;