原创力文档calotropis procera latex extract affords protection against inflammation and oxidative stress in freunds complete adjuvant-induced monoarthritis in ratscalotropis procera胶乳提取提供防止炎症和氧化应激在弗氏完全adjuvant-induced老鼠体内感染引起.pdfVIP
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calotropis procera latex extract affords protection against inflammation and oxidative stress in freunds complete adjuvant-induced monoarthritis in ratscalotropis procera胶乳提取提供防止炎症和氧化应激在弗氏完全adjuvant-induced老鼠体内感染引起
Hindawi Publishing Corporation
Mediators of Inflammation
Volume 2007, Article ID 47523, 7 pages
doi:10.1155/2007/47523
Research Article
Calotropis procera Latex Extract Affords Protection
against Inflammation and Oxidative Stress in Freund’s
Complete Adjuvant-Induced Monoarthritis in Rats
Vijay L. Kumar and Sanjeev Roy
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
Received 1 December 2006; Revised 12 February 2007; Accepted 12 February 2007
In view of the well-established anti-inflammatory properties of latex of Calotropis procera (DL), the present study was carried
out to evaluate the protective effect of its methanol extract (MeDL) against inflammation and oxidative stress in monoarthritis
induced by Freund’s complete adjuvant (FCA) in rats. Intra-articular injection of FCA produced inflammation of the joint with
a peak effect occurring on day 4 where a maximum increase in the levels of myeloperoxidase and inflammatory mediators like
PGE2 , TNF-α, and nitric oxide was observed. This was associated with oxidative stress with a marked reduction in the levels of
glutathione, catalase, superoxide dismutase and glutathione peroxidase and an increase in the lipid peroxidation as indicated by the
higher levels of thiobarbituric acid reactive substances (TBARSs). Subsequently on day 28 the histological analysis of the joint also
revealed arthritic changes. Daily treatment of rats with MeDL (50 and 500 mg/kg) and standard anti-inflammatory drug rofecoxib
(20 and 100 mg/kg), produced a significant attenuation in the inflammatory response and ameliorated the arthritic changes in
the joint. The protection afforded by MeDL and rofecoxib was more pronounced than that of phenylbutazone and was associated
with normalization of the levels of inflammatory medi
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