原创力文档can thrifty gene(s) or predictive fetal programming for thriftiness lead to obesity可以节俭基因(s)或预测胎儿编程节俭导致肥胖.pdfVIP
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can thrifty gene(s) or predictive fetal programming for thriftiness lead to obesity可以节俭基因(s)或预测胎儿编程节俭导致肥胖
Hindawi Publishing Corporation
Journal of Obesity
Volume 2011, Article ID 861049, 11 pages
doi:10.1155/2011/861049
Research Article
Can Thrifty Gene(s) or Predictive Fetal Programming for
Thriftiness Lead to Obesity?
Ulfat Baig,1 Prajakta Belsare,1 Milind Watve,1, 2 and Maithili Jog3
1 Indian Institute of Science Education and Research, Pune 411021, India
2 Anujeeva Biosciences Pvt. Ltd., Pune 411030, India
3 Department of Biotechnology, Abasaheb Garware College, Pune 411004, India
Correspondence should be addressed to Milind Watve, milind@iiserpune.ac.in
Received 7 November 2010; Accepted 18 February 2011
Academic Editor: Yvon Chagnon
Copyright © 2011 Ulfat Baig et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Obesity and related disorders are thought to have their roots in metabolic “thriftiness” that evolved to combat periodic starvation.
The association of low birth weight with obesity in later life caused a shift in the concept from thrifty gene to thrifty phenotype or
anticipatory fetal programming. The assumption of thriftiness is implicit in obesity research. We examine here, with the help of a
mathematical model, the conditions for evolution of thrifty genes or fetal programming for thriftiness. The model suggests that a
thrifty gene cannot exist in a stable polymorphic state in a population. The conditions for evolution of thrifty fetal programming
are restricted if the correlation between intrauterine and lifetime conditions is poor. Such a correlation is not observed in natural
courses of famine. If there is fetal programming for thriftiness, it could have evolved in anticipation of social
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