can bibliographic pointers for known biological data be found automatically protein interactions as a case study书目已知生物数据的指针可以自动找到作为一个案例研究蛋白质相互作用.pdfVIP

Comparative and Functional Genomics Comp Funct Genom 2001; 2: 196–206. DOI: 10.1002 / cfg.91 Research Article Can bibliographic pointers for known biological data be found automatically? Protein interactions as a case study Christian Blaschke and Alfonso Valencia* Protein Design Group, National Centre for Biotechnology, CNB-CSIC, Cantoblanco, Madrid E-28049, Spain Abstract *Correspondence to: A. Valencia, Protein Design Group, The Dictionary of Interacting Proteins (DIP) (Xenarios et al., 2000) is a large repository National Centre for of protein interactions: its March 2000 release included 237 9protein pairs whose Biotechnology, CNB-CSIC, interactions have been detected by experimental methods. Even if many of these Cantoblanco, Madrid E-28049, correspond to poorly characterized proteins, the result of massive yeast two-hybrid Spain. E-mail: valencia@cnb.uam.es screenings, as many as 851 correspond to interactions detected using direct biochemical methods. We used information retrieval technology to search automatically for sentences in Medline abstracts that support these 851 DIP interactions. Surprisingly, we found correspondence between DIP protein pairs and Medline sentences describing their interactions in only 30% of the cases. This low coverage has interesting consequences regarding the quality of annotations (references) introduced in the database and the