cancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cellscancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cells英文论文.pdfVIP

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cancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cellscancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cells英文论文.pdf

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cancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cellscancerous multi-drug resistance is reduced by leptomycin b treatment in ccrf-cemtaxol cells英文论文

Vol.4, No.10, 845-855 (2012) Health /10.4236/health.2012.410130 Cancerous multi-drug resistance is reduced by Leptomycin B treatment in CCRF-CEM/Taxol cells 1,2 3 3* Jin-Wu Zhu , Yong-Xiang Zhang , Yong-Biao Guan 1Institute of Aviation Medicine, Beijing, China 2The Fourth Military Medical University, Xi’an, China 3Beijing Institute of Pharmacology and Toxicology, Beijing, China; *Corresponding Author: GuanYB@H Received 16 August 2012; revised 13 September 2012; accepted 25 September 2012 ABSTRACT ding cause of treatment failure in cancer therapy. MDR is, in large part, a story of drug transporters [1]. Multi- Objectives: Multi-drug resistance (MDR) to che- drug transporters extrude antitumor agents from the cells motherapy remains a major obstacle to over- and promote MDR phenotypes in cancer cells, which are come in the successful treatment of patients composed of primary active transporters and secondary with cancers. It was recently discovered that Lep- active transporters. The primary transporters are repre- tomycin B (LMB) reduces the paclitaxel-induced sented by the ATP-binding cassette (ABC) transporter MDR in CCRF-CEM/Taxol cells. However, the me-