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castleman’s disease of the pleura case presentation and review of literaturecastleman病胸膜病例报告和审查的文学.pdf

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castleman’s disease of the pleura case presentation and review of literaturecastleman病胸膜病例报告和审查的文学

International Journal of Clinical Medicine, 2012, 3, 311-317 311 / 10.4236/ijcm.2012.34062 Published Online July 2012 (http://www.SciRP.org/journal/ijcm) Castleman’s Disease of the Pleura: Case Presentation and Review of Literature 1 1 1,2 3 1,2* Pablo Loarte , Nayle Araguez , Rose Marie Flores , Li-The Wu , Ronny Cohen 1Woodhull Medical Center, Brooklyn, USA; 2NYU School of Medicine, New York, USA; 3North Shore University Hospital, Forest Hills, USA. * Email: ronny.cohen@ Received March 11th, 2012; revised April 25th, 2012; accepted May 16th, 2012 ABSTRACT Purpose: Castleman’s Disease is a very rare medical disease and the presence of this condition in the pleura is even rarer and there are only few reported cases. The presence of symptoms is also unusual and has been mostly described in multicentric cases of castleman’s disease instead of solitary lesions (unicentric castleman). We report a case of unicen- tric pleural castlema’s disease with presence of constitutional symptoms. Methods: A 36-year-old male without any significant past medical history who presented to the emergency due to an incidental large pleural effusion seen in chest radiograph, but referring chronic constitutional symptoms consistent of significant weight loss and chronic cough. Re- sults: Chest computed tomography revealed a mass and several attemps with minimally invase approach failed to iden- tify the lesion. The mass was excised through VATS but due to its significant vascularity, it had to be converted to open thoracotomy. Conclusion: The treatment of unicentric lesions is mainly complete surgical excision and the prognosis is excellent with some chances of recurrence. There are less than one dozen of reported pleural castleman reported in the liter