cd8+ t-cell responses before and after structured treatment interruption in ugandan adults who initiated art with cd4+ t cells 200？cellμl the dart trial sti substudycd8 + t细胞反应前后结构治疗中断在乌干达成年人开始艺术与cd4 + t细胞200 cellμl sti substudy dart审判.pdfVIP

Hindawi Publishing Corporation AIDS Research and Treatment Volume 2011, Article ID 875028, 10 pages doi:10.1155/2011/875028 Research Article CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells 200 Cell/µL: The DART Trial STI Substudy Jennifer Serwanga,1 Susan Mugaba,1 Auma Betty,1 Edward Pimego,1 Sarah Walker,2 Paula Munderi,1 Charles Gilks,3 Frances Gotch,4 Heiner Grosskurth,1, 5 and Pontiano Kaleebu1 1 MRC/UVRI Uganda Research Unit on AIDS, 51-59 Nakiwogo Road, Entebbe, Uganda 2 MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK 3 Imperial College London, South Kensington Campus, London SW7 2AZ, UK 4 Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London SW10 9NH, UK 5 London School of Hygiene Tropical Medicine, University of London, London WC1E 7HT, UK Correspondence should be addressed to Jennifer Serwanga, jennifer.serwanga@ Received 27 May 2010; Accepted 15 December 2010 Academic Editor: Joep Lange Copyright © 2011 Jennifer Serwanga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN-γ and Perforin responses were compared in STI (n = 42) and continuous treatment (CT) (n = 46) before and after a single STI cycle