cell death mechanisms at the maternal-fetal interface insights into the role of granulysin细胞死亡机制在母胎界面的见解granulysin的角色.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 180272, 8 pages doi:10.1155/2012/180272 Review Article Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin Danijela Veljkovic Vujaklija,1, 2 Sonja Sucic,1, 3 Tamara Gulic,1 Marin Dominovic,1 and Daniel Rukavina1 1 Department of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, Croatia 2 Department of Radiology, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia 3 Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, 1090 Vienna, Austria Correspondence should be addressed to Daniel Rukavina, daniel@medri.hr Received 31 May 2011; Revised 12 July 2011; Accepted 12 July 2011 Academic Editor: Andres Salumets Copyright © 2012 Danijela Veljkovic Vujaklija et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sw