cellular interplay between cardiomyocytes and nonmyocytes in cardiac remodeling心肌细胞之间的细胞相互作用和nonmyocytes心脏重塑.pdfVIP

SAGE-Hindawi Access to Research International Journal of Inflammation Volume 2011, Article ID 535241, 13 pages doi:10.4061/2011/535241 Review Article Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling Norifumi Takeda1, 2 and Ichiro Manabe2, 3 1 Department of Cell and Developmental Biology and Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA 2 Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan 3 Global COE Program, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan Correspondence should be addressed to Ichiro Manabe, manabe-tky@umin.ac.jp Received 22 March 2011; Revised 28 May 2011; Accepted 12 June 2011 Academic Editor: Masanori Aikawa Copyright © 2011 N. Takeda and I. Manabe. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cardiac hypertrophy entails complex structural remodeling involving rearrangement of muscle fibers, interstitial fibrosis, ac- cumulation of extracellular matrix, and angiogenesis. Many of the processes underlying cardiac remodeling have features in common with chronic inflammatory processes. During these processes, nonmyocytes, such as endothelial cells, fibroblasts, and immune cells, residing in or infiltrating into the myocardial interstitium play active roles. This paper mainly addresses the functional roles of nonmyocytes during cardiac remodeling. In particular, we focus on the communication between cardiomyo- cytes and nonmyocyt