cellular responding kinetics based on a model of gene regulatory networks under radiotherapy细胞的反应动力学模型基础上的基因调控网络在放射治疗.pdfVIP

Vol.2, No.2, 137-146 (2010) Health doi:10.4236/health.2010.22021 Cellular responding kinetics based on a model of gene regulatory networks under radiotherapy 1,3* 1,2,3* 1 1 1,2 Jin-Peng Qi , Yong-Sheng Ding , Shi-Huang Shao , Xian-Hui Zeng , Kuo-Chen Chou 1College of Information Sciences and Technology, Donghua University, Shanghai, China 2Gordon Life Science Institute, San Diego, USA; qipengkai@126.com, ysding@ 3Engineering Research Center of Digitized Textile Fashion Technology, Ministry of Education, Donghua University, Shanghai, China Received 16 November 2009; revised 3 December 2009; accepted 8 December 2009. ABSTRACT is the most commonly known specific target of mutation in tumorigenesis [4]. Abnormalities in the P53 have been Radiotherapy can cause DNA damage into cells, identified in over 60% of human cancers and the status of triggering the cell cycle arrest and cell apop- P53 within tumor cells has been proposed to be one of the tosis through complicated interactions among determinant response to anticancer therapies [3,4]. Con- vital genes and their signal pathways. In order to trolled radiotherapy studies show the existence of a strong in-depth study the complicated cellular res- biologic basis for considering P53 status as a radiation ponses under such a circumstance, a novel mo- predictor [3,5]. Therefore, the status of P53 in tumor cell del for P5