cellular prion protein and sexual dimorphic areas in rodents. correlates with alzheimer disease细胞的朊蛋白和性二态的地区啮齿动物。.pdfVIP
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cellular prion protein and sexual dimorphic areas in rodents. correlates with alzheimer disease细胞的朊蛋白和性二态的地区啮齿动物。
Neuroscience Medicine, 2011, 2, 384-391
doi:10.4236/nm.2011.24051 Published Online December 2011 (http://www.SciRP.org/journal/nm)
Cellular Prion Protein and Sexual Dimorphic
Areas in Rodents. Correlates with Alzheimer
Disease
1 1* 1 2,3 1,2
Mar Cuadrado-Tejedor , Ana Irujo , Beatriz Paternain , María Jesús Madrid , José Luis Velayos
1Department of Anatomy, Faculty of Medicine, University of Navarra, Pamplona, Spain; 2IMMA (Institute of Applied Molecular
Medicine), Faculty of Medicine, University San Pablo CEU, Boadilla dl Monte, Madrid, Spain; 3Department of Basic Medical Sci-
ences, University San Pablo-CEU, Boadilla dl Monte, Madrid, Spain.
*
E-mail: airujo@unav.es
Received October 6th, 2011; revised November 20th, 2011; accepted November 29th, 2011.
ABSTRACT
The cellular prion protein (PrPC) expression was analyzed by western-blot in the rat, in two different dimorphic brain
areas such as the anterior hypothalamic and the preoptic areas. In both cases, the PrPC expression was increased in
males, implying a sexual dimorphism for the PrPC protein. The study was also made in other two brain areas, frontal
cortex and hyppocampus (a clearly dimorphic area); in this case, mice of different ages of both sexes were used. In both
brain areas analyzed, although the PrPC expression was increased with age until the adult age (38 weeks), it was de-
creased in aged animals (56 weeks) in both sexes. The PrPC expression in mouse hippocampus was predominant in
males in comparison to females. Moreover, the non-glycosylated band was increased with age and this increase was
parallel with the increase observed for the glycolsylated band. The non-glycosylated band increases more in aged fe-
males. Altogether, these data suggest that PrP in rodents, in the brain areas analyzed, has a dimo
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