brain interactions between extinction and reconsolidation in the treatment of fear memories大脑灭绝之间的相互作用和重新整合治疗恐惧记忆.pdfVIP

Neuroscience Medicine, 2011, 2, 232-238 doi:10.4236/nm.2011.23032 Published Online September 2011 (http://www.SciRP.org/journal/nm) Brain Interactions between Extinction and Reconsolidation in the Treatment of Fear Memories 1 1 1 1, 2 Dagieli Sartor , Natália Gindri Fiorenza , Jociane de Carvalho Myskiw , Iván Izquierdo 1Centro de Memória, Instituto do Cérebro, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil; 2 National Institute of Translational Neuroscience, National Research Council of Brazil and Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. Email: Izquier@.br Received July 4th, 2011; revised July 25th, 2011; accepted August 6th, 2011. ABSTRACT Memory traces become labile at the time of retrieval , and this initiates two protein synthesis-dependent processes in the brain: extinction, which inhibits their further retrieval, and reconsolidation, which may enhance retrieval or change the memory’s content. Extinction may itself suffer reconsolidation. Interactions between these processes may be applied to the treatment of fear memories, such as those underlying the post-traumatic stress disorder. Keywords : Memory, Extinction Learning, Reconsolidation, Fear Memories 1. Introduction somewhat earlier than extinction processes in the central nervous system of crabs [9]. It would be impractical if Memories can be modified in many ways after they are reconsolidation mechanisms were activated after extinct- consolidated. The two best known and most widely stud-