bioinorganic chemistry in thyroid gland effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions生物无机化学在甲状腺抗甲状腺药物对peroxidase-catalyzed氧化和碘化反应的影响.pdfVIP

Hindawi Publishing Corporation Bioinorganic Chemistry and Applications Volume 2006, Article ID 23214, Pages 1–9 DOI 10.1155/BCA/2006/23214 Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions Gouriprasanna Roy and G. Mugesh Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India Received 19 June 2006; Accepted 29 August 2006 Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the se- lenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)-catalyzed oxidation and iodination reactions by antithy- roid drugs are described. Copyright © 2006 G. Roy and G. Mugesh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION selenolate) group of the enzyme (E-SeH or E-Se ) first re- acts