cell-ploc 2.0 an improved package of web-servers for predicting subcellular localization of proteins in various organismscell-ploc 2.0 web服务器的改进方案预测蛋白质的亚细胞定位在不同的生物体.pdfVIP

Vol.2, No.10, 1090-1103 (2010) Natural Science /10.4236/ns.2010.210136 Cell-PLoc 2.0: an improved package of web-servers for predicting subcellular localization of proteins in various organisms Kuo-Chen Chou1,2, Hong-Bin Shen1,2 1Gordon Life Science Institute, 13784 Torrey Del Mar Drive, San Diego, CA 92130, USA; kcchou@ 2Institute of Image Processing Pattern Recognition, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China; hbshen@ Received 5 August 2010; revised 8 September 2010; accepted 12 September 2010. ABSTRACT most important attributes. It can provide useful insight about the function of the protein. It is also fundamental Cell-PLoc 2.0 is a package of web-servers to system biology because knowledge of the subcellu- evolved from Cell-PLoc (Chou, K.C. Shen, lar locations of proteins is indispensable for in-depth H.B., Nature Protocols, 2008, 2:153-162) by a understanding how the biological processes are regu- top-down approach to improve the power for lated by the intricate pathways at the cellular level predicting subcellular localization of proteins in [1,2]. Particularly, the information of protein subcel- various organisms. It contains six predictors: Euk-mPLoc 2.0, Hum-mPLoc 2.0, Plant-mPLoc, lula