cell therapies for heart function recovery focus on myocardial tissue engineering and nanotechnologies细胞治疗心脏功能恢复关注心肌组织工程和纳米技术.pdfVIP

Hindawi Publishing Corporation Cardiology Research and Practice Volume 2012, Article ID 971614, 10 pages doi:10.1155/2012/971614 Review Article Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies ¨ 1 ´ 2, 3 2 Marie-Noelle Giraud, Anne Geraldine Guex, and Hendrik T. Tevaearai 1 Cardiology, Department of Medicine, Faculty of Science, University of Fribourg, Chemin du Musee 5, ´ 1700 Fribourg, Switzerland 2 Clinic for Cardiovascular Surgery, Inselspital Berne, Berne University Hospital and University of Berne, Switzerland 3 Empa, Swiss Federal Laboratories for Material Science and Technology, 9014 St. Gallen, Switzerland ¨ Correspondence should be addressed to Marie-Noelle Giraud, marie-noelle.giraud@unifr.ch Received 29 July 2011; Accepted 6 February 2012 Academic Editor: Daryll M. Baker ¨ Copyright © 2012 Marie-Noelle Giraud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myo- cardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could