cell-type-specific differentiation and molecular profiles in skin transplantation implication of medical approach for genetic skin diseasescell-type-specific分化和分子概要文件在皮肤移植影响医疗方法的遗传疾病.pdfVIP

Hindawi Publishing Corporation Journal of Transplantation Volume 2011, Article ID 501857, 6 pages doi:10.1155/2011/501857 Review Article Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases Noritaka Oyama1, 2 and Fumio Kaneko1 1 Institute of Dermato-Immunology and Allergy, Southern Tohoku Research Institute for Neuroscience, Koriyama, Fukushima 963-8563, Japan 2 Institute of Dermato-Immunology and Allergy, Research Institute for Neuroscience, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan Correspondence should be addressed to Noritaka Oyama, norider@wine.plala.or.jp Received 1 June 2011; Accepted 7 September 2011 Academic Editor: Matthew Griffin Copyright © 2011 N. Oyama and F. Kaneko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Skin is highly accessible and valuable organ, which holds promise to accelerate the understanding of future medical innovation in association with skin transplantation, engineering, and wound healing. In skin transplantation biology, multistage and multifocal damages occur in both grafted donor and perilesional host skin and need to be repaired properly for the engraftment and maintenance of characteristic skin architecture. These local events are more unlikely to be regulated by the host immunity, because human skin transplantation has accomplished the donor skin engraftment onto the immunocompromised or immunosuppressive animals. Recent studies have emerged the importance of α-smooth muscle actin- (SMA-) positive myofibr