cd38 expression on cd8+ cells—its influence on development of tuberculosis in hiv positive individualscd8 + cd38表情cells-its影响肺结核在hiv阳性个体的发展.pdfVIP

Vol.2, No.2, 65-71 (2012) Open Journal of Immunology /10.4236/oji.2012.22008 CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals 1 2 1 Ramaseri Sunder Sharada , Hanumanth Surekha Rani , Satya Sudheer Pydi , Jonnalagada Subbanna1, Vijaya lakshmi Valluri1* 1Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health Research Centre, Hyderabad, India; * Corresponding Author: vijayavalluri@ 2Department of Genetics, Osmania University, Hyderabad, India Received 14 February 2012; revised 20 March 2012; accepted 5 April 2012 ABSTRACT liferative response to HIV-specific antigen is well estab- lished in long-term non-progressors than those with more CD38 expression on CD8+ cells seems to cor- rapid progression [2]. relate well with HIV viral-loads, while the ex- It is well-known that CD4+ cells decline during infec- pression levels are thought to be low in patients tion with HIV and the numbers reduce further with dis- with tuberculosis. This study aimed at deter- ease progression [3]. Reduction in the number of periph- mining the levels of CD38 expression in HIV+ eral CD4+ T cells in patients with active tuberculosis individuals who develop tuberculosis. Expres- also and restoration to norm