cell replication and angiogenesis in central nervous system tumors and their relationship with the expression of tissue prolactin and hyperprolactinemia细胞复制和中枢神经系统肿瘤中血管生成及其与组织催乳素和高泌乳素血症的表达之间的关系.pdfVIP

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cell replication and angiogenesis in central nervous system tumors and their relationship with the expression of tissue prolactin and hyperprolactinemia细胞复制和中枢神经系统肿瘤中血管生成及其与组织催乳素和高泌乳素血症的表达之间的关系.pdf

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cell replication and angiogenesis in central nervous system tumors and their relationship with the expression of tissue prolactin and hyperprolactinemia细胞复制和中枢神经系统肿瘤中血管生成及其与组织催乳素和高泌乳素血症的表达之间的关系

Open Journal of Pathology, 2012, 2, 50-57 Published Online July 2012 (http://www.SciRP.org/journal/ojpathology) /10.4236/ojpathology.2012.23011 Cell Replication and Angiogenesis in Central Nervous System Tumors and Their Relationship with the Expression of Tissue Prolactin and Hyperprolactinemia Denise M. D. Abech, Júlia F. S. Pereira-Lima, Carolina G. S. Leães, Rosalva T. Meurer, * Lígia M. Barbosa-Coutinho, Nelson P. Ferreira, Miriam C. Oliveira Center for Neuroendocrinology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil. * Email: mco@.br Received April 19th, 2012; revised May 11th, 2012; accepted May 24th, 2012 ABSTRACT This study aimed to assess the effect of intracellular prolactin (ICPRL) and hyperprolactinemia on cell replication, using an immunohistochemical (IHC) technique for Ki-67 and Mcm-2, and angiogenesis, using IHC for endoglin CD-105, in central nervous system (CNS) tumors. This cross-sectional study included 79 cases of surgically excised primary CNS tumors of neuroepithelial origin (41.8% of all cases: 10.2% astrocytomas, 24% glioblastomas and 7.6% oligodendro- gliomas) and meningeal origin (58.2% of all cases). Ki-67 and Mcm-2 indexes were calculated as a percentage of marked cells. The medians for Ki-67 and Mcm-2 indexes were significantly lower in meningiomas than in glioblas- tomas (p 0.001 for Ki-67 and p 0.001 for Mcm-2) and oligodendrogliomas (p 0.001 for Ki-67 and p = 0.02 for Mcm-2). A good correlation was observed between the Ki-67 and Mcm-2 (rS = 0.60) replication markers. There were no significant differences in vascular density between the different histological types. Immunohistochemistry for ICPRL was positive in 45.6% of the tumors. Serum prolactin (PRL) was elevated in 30.6% of the cases. Multipl