changes in weight and metabolic parameters following long-term iloperidone use a meta-analysis of data from 9 phase ii and iii trials of iloperidone体重和代谢参数变化后长期iloperidone使用一个荟萃分析的数据从9 iloperidone的第二和第三阶段试验.pdfVIP
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changes in weight and metabolic parameters following long-term iloperidone use a meta-analysis of data from 9 phase ii and iii trials of iloperidone体重和代谢参数变化后长期iloperidone使用一个荟萃分析的数据从9 iloperidone的第二和第三阶段试验
Open Journal of Psychiatry, 2012, 2, 414-422 OJPsych
/10.4236/ojpsych.2012.224058 Published Online November 2012 (http://www.SciRP.org/journal/ojpsych/)
Changes in weight and metabolic parameters following
long-term iloperidone use: A meta-analysis of data from 9
Phase II and III trials of iloperidone*
Marla Hochfeld, Saeeduddin Ahmed, Xiangyi Meng, Adam Winseck
Novartis Pharmaceuticals Corporation, East Hanover, USA
Email: marla.hochfeld@
Received 10 September 2012; revised 9 October 2012; accepted 18 October 2012
ABSTRACT can predispose patients with schizophrenia to disease,
some antipsychotic medications are associated with
Objective: To determine the impact of iloperidone
weight gain and changes in glucose and lipids [5-7].
treatment on metabolic parameters. Methods: Data
Each antipsychotic drug has a different metabolic profile,
were analyzed from 3210 patients who received ilop-
in part because of their unique receptor-binding patterns
eridone and 587 patients who received placebo for up
[8]. Monitoring patients’ metabolic profile during antip-
to 2 years during 9 Phase II and Phase III studies
sychotic drug use is therefore an important part of patient
(integrated safety database). Patients were pooled by
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