changing concepts of “latent tuberculosis infection” in patients living with hiv infection改变u201c潜伏结核感染u201d的概念与艾滋病毒感染患者.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 980594, 9 pages doi:10.1155/2011/980594 Review Article Changing Concepts of “Latent Tuberculosis Infection” in Patients Living with HIV Infection Stephen D. Lawn,1, 2 Robin Wood,1 and Robert J. Wilkinson3, 4, 5 1 The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa 2 Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK 3 Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa 4 Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK 5 Division of Medicine, Imperial College London, London W2 1PG, UK Correspondence should be addressed to Stephen D. Lawn, stevelawn@yahoo.co.uk Received 9 June 2010; Accepted 25 August 2010 Academic Editor: Estee Torok Copyright © 2011 Stephen D. Lawn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. One third of the world’s population is estimated to be infected with Mycobacterium tuberculosis, representing a huge reservoir of potential tuberculosis (TB) disease. Risk of progression to active TB is highest in those with HIV coinfection. However, the nature of the host-pathogen relationship in those with “lat