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coherent estimates of genetic effects with missing information相干估计信息缺失的基因的影响
Open Journal of Genetics, 2012, 2, 31-38 OJGen
/10.4236/ojgen.2012.21003 Published Online March 2012 (http://www.SciRP.org/journal/ojgen/)
Coherent estimates of genetic effects with missing
information
1 2,3 4 3,4
Carl Nettelblad , Örjan Carlborg , Ania Pino-Querido , José M. Álvarez-Castro
1Department of Information Technology, Uppsala University, Uppsala, Sweden
2Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden
3Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
4Department of Genetics, University of Santiago de Compostela, Lugo, Spain
Email: jose.alvarez.castro@usc.es
Received 15 December 2011; revised 21 January 2012; accepted 6 February 2012
ABSTRACT of a phenotype in a particular population [1]. In these
experiments, models of genetic effects, also called geno-
Genetic effect estimates for loci detected in quantita-
type-to-phenotype maps [2], enable researchers to evalu-
tive trait locus (QTL) mapping experiments depend
ate the effects of allele substitutions in positions across
upon two factors. First, they are parameterizations of
the genome. In QTL mapping, these models are thus
the genotypic values determined by the model of ge-
used in a reverse m
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