盐酸羟考酮控释片治疗晚期癌症疼痛疗效观察.docVIP

盐酸羟考酮控释片治疗晚期癌症疼痛疗效观察[摘要] 目的 观察盐酸羟考酮控释片(奥施康定 oxycontin)治疗晚期癌症中、重度疼痛的临床效果、不良反应及患者生活质量的改善情况。方法 83例中、重度疼痛患者给予奥施康定镇痛治疗,初始剂量10mg/12h,根据疼痛情况调整剂量,直至患者患者无痛或基本无痛。结果 83例中重度癌痛患者,未缓解3例,轻度缓解6例,中度缓解19例,明显缓解39例,完全缓解16例,中度以上缓解率89.2%。治疗前平均KPS评分(60.8±6.4)分,治疗后(71.9±7.3)分,生活质量治疗后较治疗前明显改善(P0.05)。不良反应主要为便秘26例(31.3%)。结论 盐酸羟考酮控释片能有效控制癌痛,改善生活质量,且不良反应轻微。 [关键词] 盐酸羟考酮控释片;癌痛;镇痛剂 [中图分类号] R969.4[文献标识码]A [文章编号] Clinical Efficacy of Oxycodone Hydrochloride Controlled -release Tablets in the Treatment of Terminal Cancer Pain. Weiweiheng,Peoplehospital of Huiyang,Huizhou, Guangdong,516211 [Abstracts] Objective To observe the clinical effect and side effects of oxycodone hydrochloride controlled-realese tablets in the treatment of moderate to severe pain in patients with terminal cancer and to observe the improvement on the cancer patients? quality of life. Methods 83 cases of patients with moderate or severe cancer pain were treated with oxycodone hydrochloride controlled-realese tablets.The initial dose was 10mg/12h,and titrated upwards according to the extent of pain relief.Results Among all the 83 patients suffering moderate and severe cancer pain,6 cases achieved slightly pain relief,the moderate,obvious,and complete pain relief occurred in 19,39,16 patients respectively.The kamosfsky mark after treatment(71.9±7.3)was higher than before (60.8±6.4),the quality of life after treatment was improved obviously than before(P0.05).Main adverse effect was constipation in 26 (31.3%).Conclusion The hydrochloride controlled-realese tablets can effectively control cancer pain,improve the living quality,and the adverse effect was slight. [Key words]oxycodone hydrochloride controlled-realese tablets;cancer pain;analgesic 疼痛是晚期癌症患者的常见症状,我国现有癌症患者200多万,每年新发生的癌症患者约160万,疼痛发生率40%-50%,50%患者的疼痛为中至重度,其中30%为难以忍受的重度疼痛。持续性或阵发性疼痛往往引起抑郁、焦虑、睡眠、心理及人际交往障碍,直接影响患者的生活质量[1]。疼痛先作为第五生命体征,与体温、呼吸、脉搏、血压4个生命体征应受到同等重视。癌症疼痛从心理、生理、精神和社会多个方面影响患者的生存质量,镇痛治疗意义深远。盐酸羟考酮控释片(商品名:奥施康定)是一种新型强阿片类镇痛剂。其主要特点是有即释和控释两种释放方式,起效迅速,控释全程[2]。我