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comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs比较基因组评估新型广谱抗菌药物的目标
Comparative and Functional Genomics
Comp Funct Genom 2004; 5: 304–327.
Published online in Wiley InterScience (). DOI: 10.1002/cfg.411
Research Article
Comparative genomic assessment of novel
broad-spectrum targets for antibacterial
drugs
1 2
Thomas A. White and Douglas B. Kell *
1Department of Biology, University of York, Box 373, Heslington, York YO10 5YW, UK
2 Department of Chemistry, UMIST, Faraday Building, Sackville St, PO Box 88, Manchester M60 1QD, UK
*Correspondence to: Abstract
Douglas B. Kell, Department of
Chemistry, UMIST, Faraday Single and multiple resistance to antibacterial drugs currently in use is spreading,
Building, Sackville Street, PO Box since they act against only a very small number of molecular targets; finding novel
88, Manchester, M60 1QD, UK. targets for anti-infectives is therefore of great importance. All protein sequences from
E-mail: dbk@umist.ac.uk three pathogens (Staphylococcus aureus, Mycobacterium tuberculosis and Escherichia
coli O157:H7 EDL993) were assessed via comparative genomics methods for their
suitability as antibacterial targets according to a number of criteria, including the
essentiality of the protein, its level of sequence conservation, and its distribution in
pathogens, bacteria and eukaryotes (especially humans). Each protein was scored and
ranked based on weighted variants of these criteria in order to prioritize proteins as
potential novel broad-spectrum targets for antibacterial drugs. A number of proteins
proved to score highly
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