comparison of 4-weekly vs 3-weekly gemcitabine as adjuvant chemotherapy following curative resection for biliary tract cancer a prospective randomized controlled trial四周vs抓捕比较吉西他滨作为胆道癌切除后辅助化疗治疗前瞻性随机对照试验.pdfVIP

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comparison of 4-weekly vs 3-weekly gemcitabine as adjuvant chemotherapy following curative resection for biliary tract cancer a prospective randomized controlled trial四周vs抓捕比较吉西他滨作为胆道癌切除后辅助化疗治疗前瞻性随机对照试验.pdf

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comparison of 4-weekly vs 3-weekly gemcitabine as adjuvant chemotherapy following curative resection for biliary tract cancer a prospective randomized controlled trial四周vs抓捕比较吉西他滨作为胆道癌切除后辅助化疗治疗前瞻性随机对照试验

Journal of Cancer Therapy, 2011, 2, 703-709 703 doi:10.4236/jct.2011.25095 Published Online December 2011 (http://www.SciRP.org/journal/jct) Comparison of 4-Weekly vs 3-Weekly Gemcitabine as Adjuvant Chemotherapy Following Curative Resection for Biliary Tract Cancer: A Prospective Randomized Controlled Trial 1 2* 3 4 5 Shogo Kobayashi , Atsushi Miyamoto , Junzo Shimizu , Masaki Kashiwazaki , Yutaka Takeda , Shigeyuki Ueshima6 7 1 3 1 , Yongkook Kim , Toru Kitagawa , Keizo Dono , Masaki Mori , Yuichiro Doki1, Hiroaki Nagano1 1Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan; 2Department of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan; 3Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan; 4Department of Surgery, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan; 5Department of Surgery, Kansai Rosai Hos- pital, Amagasaki, Japan; 6Department of Surgery, Osaka Police Hospital, Osaka, Japan; 7Department of Surgery, Osaka Rosai Hos- pital, Sakai, Japan. * E-mail: amiyamo@onh.go.jp Received August 28th, 2011; revised September 30th, 2011; accepted October 15th, 2011. ABSTRACT Background : Surgery for biliary tract cancer, including pancreatoduodenectomy and major hepatectomy, is too ag- gressive and does not allow postoperative gemcitabine to be administered by the usual dosage protocol . We hypothe- sized that the feasibility of 3-weekly protocol (days 1 and 8, every 3 weeks) of adjuvant gemcitabine therapy may be superior to the usual 4-weekly protocol (days 1, 8, and 15 every 4 weeks). Method