coccoid helicobacter pylori can directly adhere and invade in agminated formation to human gastric epithelial cells球菌样的幽门螺杆菌可以直接遵循和入侵人类胃上皮细胞的聚集的形成.pdfVIP

Advances in Microbiology, 2012, 2, 112-116 /10.4236/aim.2012.22015 Published Online June 2012 (http://www.SciRP.org/journal/aim) Coccoid Helicobacter pylori Can Directly Adhere and Invade in Agminated Formation to Human Gastric Epithelial Cells 1,2* 3* 2 2 4 Nagahito Saito , Hong-Kean Ooi , Kohei Konishi , Eriko Shoji , Mototsugu Kato , Masahiro Asaka2 1Internal Medicine, Nemuro City Hospital, Nemuro, Japan 2Gastroenterology and Hematology Section, Graduate School of Medicine, Hokkaido University, Sapporo, Japan 3Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan 4Division of Endoscopy, Hokkaido University of Medical Hospital, Sapporo, Japan * * Email: nagahitosaito@k7.dion.ne.jp, hkooi@.tw Received March 7, 2012; revised March 22, 2012; accepted April 5, 2012 ABSTRACT Helicobacter pylori (H. pylori) can infect into the epithelial cell to cause benign or malignant disorders. Under stressful environment, a spiral form of H. pylori is transformed into a coccoid form. The infectivity of the coccoid form is still controversial. Since spiral forms are transformed into two types of coccoid forms via different mechanisms, the infec- tivity of the two types of coccoid forms into human gastric epithelial cell was examined. A laboratory and a clinical strain of H. pylori were cultured in liquid medium under different conditions to produce the two types of coccoid forms. These coccoid H.