原创力文档computational evaluation of the dynamic minimal model for the root causes of hypoglycemia动态最小模型的计算评价过低的根本原因.pdfVIP
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computational evaluation of the dynamic minimal model for the root causes of hypoglycemia动态最小模型的计算评价过低的根本原因
J. Biomedical Science and Engineering, 2011, 4, 391-396 JBiSE
doi:10.4236/jbise.2011.45049 Published Online May 2011 (http://www.SciRP.org/journal/jbise/).
Computational evaluation of the dynamic minimal model for
the root causes of hypoglycemia
Murat Tunç, Sedat Şişbot, A. Kaya Gülkaya
Yeditepe University, Engineering Faculty, System Engineering Department, Istanbul, Turkey.
Email: tuncmu@.tr, ssisbot@.tr, kayagulkaya@
Received 4 March 2011; revised 20 March 2011; accepted 8 April 2011.
ABSTRACT Hypoglycemia refers to low plasma glucose concen-
tration which is associated by specific symptoms such as
This research is an attempt to validate how glu-
shakiness, nervousness, changes in awareness. Depend-
cose-insulin dynamic mathematical model facilitate
ing on the population blood glucose levels below 70
to identify the root causes for hypoglycaemia. The
mg/dl can be associated with clinical hypoglycemia.
purpose is to determine whether increased insulin
Hypoglycemia that occurs after food intake is called
sensitivity or increased insulin secretion causes post-
post-prandial hypoglycemia and this may precede the
prandial hypoglycemic (PPH) response, by linking
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