contribution of cholesterol and oxysterols in the physiopathology of cataract implication for the development of pharmacological treatments贡献的胆固醇和oxysterols白内障影响的生理病理学发展的药理治疗.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2011, Article ID 471947, 6 pages doi:10.1155/2011/471947 Review Article Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract: Implication for the Development of Pharmacological Treatments 1, 2 3 ´ 2 Anne Vejux, Mohammad Samadi, and Gerard Lizard 1 Inserm-CIT 808, CHU de Besanc¸on, 25030 Besanc¸on, France 2 Equipe Biochimie M´etabolique et Nutritionnelle Centre de Recherche INSERM 866 (Lipides, Nutrition, Cancer), Facult´e des Sciences Gabriel, Universit´e de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France 3 LCME/D´epartement de Chimie, Universit´e Paul Verlaine-Metz, 57012 Metz, France ´ Correspondence should be addressed to Gerard Lizard, gerard.lizard@u-bourgogne.fr Received 23 November 2010; Revised 18 January 2011; Accepted 10 February 2011 Academic Editor: Jie Jin Wang Copyright © 2011 Anne Vejux et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The development of cataract is associated with some lipid changes in human lens fibers, especially with increased accumulation and redistribution of cholesterol inside these cells. Some direct and indirect lines of evidence, also suggest an involvement of cholesterol oxide derivatives (also named oxysterols) in the development of cataract. Oxysterol formation can result either from nonenzymatic or enzymatic processes, and some oxysterols can induce a wide range of cytotoxic effects (overproduction of reactive oxygen spec