conformational behavior of stereo regular substituted polyglycolides is side chain dependent立体构象行为的正则替换polyglycolides侧链相关的.pdfVIP

Vol.2, No.3, 285-299 (2011) Journal of Biophysical Chemistry doi:10.4236/jbpc.2011.23033 Conformational behavior of stereo regular substituted polyglycolides is side chain dependent * Fateh S. Nandel , Roobee Garla * Department of Biophysics, Panjab University, Chandigarh, India; Corresponding Author: fateh_nandel@ Received 8 April 2011; revised 13 May 2011; accepted 17 May 2011. ABSTRACT backbone. Substituted polyglycolides having two asym- Keywords: Polyglycolides; Conformation; metric centers are attractive alternatives to ma- 27 Ribbon Type Structure; Helical Structure without terials derived from petroleum because of their Hydrogen Bonds; Carbonyl-Carbonyl Interactions; biocompatibility and biodegradability. The con- Simulation Studies formational behavior of various substituted po- lyglycolides has been investigated by both quantum mechanical and molecular dynamics 1. INTRODUCTION approaches. Polymethylglycolide (polylactide) Conventional polymers such as polyethylene, poly- and polyphenylmethylglycolide in RS or SR propylene and polystyrene persist for many years after forms are predicted to adopt 27 ribbon type disposal due to their resistance to degradation which structures with φ, ψ values of ±30, ±50 or ∓30 or creates serious environmental problems. This has lead to ∓50 respectively stabilised by carbonyl-carbonyl the search of biodegradable polymers which degrade by