coordination reactions and noncovalent interactions of polyamines with nucleotides in binary systems and with nucleotides and copper(ii) ion in ternary systems协调反应和共价相互作用的多胺与核苷酸在双星系统和核苷酸和铜(ii)离子在三元系统.pdfVIP

Hindawi Publishing Corporation Bioinorganic Chemistry and Applications Volume 2010, Article ID 740435, 13 pages doi:10.1155/2010/740435 Research Article Coordination Reactions and Noncovalent Interactions of Polyamines with Nucleotides in Binary Systems and with Nucleotides and Copper(II) Ion in Ternary Systems Lechoslaw Lomozik,1, 2 Anna Gasowska,1 Grzegorz Krzysko,1 and Romualda Bregier-Jarzebowska1 1 Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznan, Poland 2 Faculty of Chemical Technology and Engineering, University of Technology and Life Sciences, 85-225 Bydgoszcz, Poland Correspondence should be addressed to Lechoslaw Lomozik, lomozik@.pl Received 22 February 2010; Revised 21 June 2010; Accepted 29 June 2010 Academic Editor: Giovanni Natile Copyright © 2010 Lechoslaw Lomozik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Interactions of nucleotides (AMP, CMP) and 1,2-diaminopropane (tn-1) or 2-methyl-1,2-diaminopropane (tn-2) in metal-free systems as well as in the systems including copper(II) ions were studied. The composition and overall stability constants of the complexes formed were determined by the potentiometric method, whereas the interaction centres and coordination sites were identified by spectroscopic methods. It was found that phosphate groups of nucleotides and the protonated amine groups of polyamines are the centres of interaction. The differences in the interactions with the polyamines which act as models of biogenic amines are impacted by the presence of lateral chains (methylene groups) in tn-1 and tn-2. In the ternary systems with Cu(II)