原创力文档determination of sedative component in chinese medicines by high resolution chromatography-electron impact-mass spectrometry确定中药的镇静剂组件高分辨率chromatography-electron impact-mass谱分析.pdfVIP
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determination of sedative component in chinese medicines by high resolution chromatography-electron impact-mass spectrometry确定中药的镇静剂组件高分辨率chromatography-electron impact-mass谱分析
Journal of Analytical Sciences, Methods and Instrumentation, 2012, 2, 13-17 13
/10.4236/jasmi.2012.21003 Published Online March 2012 (http://www.SciRP.org/journal/jasmi)
Determination of Sedative Component in Chinese
Medicines by High Resolution Chromatography-Electron
Impact-Mass Spectrometry
1* 1 2 1
Changming Zhang , Dongmei Huang , Qiuxia Cheng , Zhanggen Huang
1State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan, China; 2Shanxi
Northern Xing’an Chemical Industry Co., Ltd., Taiyuan, China.
*
Email: zhangcm@
th st nd
Received October 18 , 2011; revised November 21 , 2011; accepted December 2 , 2011
ABSTRACT
The sedative compounds in two traditional Chinese medicines were studied. These compounds are present in the me-
dicinal herbs “Zao Ren” and “Lu Lu Tong”. The samples were first extracted by ethanol and pre-treated by ultrasonic
wave, and then they were separated and qualitatively analyzed by high-resolution GC-EI-MS and High Performance
Liquid Chromatography (HPLC) systems. We have found that the Chinese herb medicines “Zao Ren” contained
clonazepam (120 ppm), whereas “Lu Lu Tong” Chinese drug contained estazolam (270 ppm). The Analytical meas-
urements were done by using three different diagnostic indices using the GC-retention time of the GC-EI-MS total-ion-
chromatogram; single stage EI-MS analysis identification and from the measurements of the retention time in the
HPLC.
Keywords: Chinese Medicine; GC-EI-MS; HPLC; Clonazepam; Estazolam
1. Introduction logica
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