dietary conjugated linoleic acid and hepatic steatosis species-specific effects on liver and adipose lipid metabolism and gene expression饮食共轭亚油酸,肝脂肪变性特有对肝脏和脂肪脂质代谢和基因表达的影响.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2012, Article ID 932928, 13 pages doi:10.1155/2012/932928 Review Article Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression Diwakar Vyas,1 Anil Kumar G. Kadegowda,2 and Richard A. Erdman1 1 Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA 2 Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA Correspondence should be addressed to Diwakar Vyas, dvyas@ Received 15 May 2011; Accepted 22 June 2011 Academic Editor: Konstantinos Kantartzis Copyright © 2012 Diwakar Vyas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To summarize the recent studies on effect of conjugated linoleic acid (CLA) on hepatic steatosis and hepatic and adipose lipid metabolism highlighting the potential regulatory mechanisms. Methods. Sixty-four published experiments were summarized in which trans-10, cis-12 CLA was fed either alone or in combination with other CLA isomers to mice, rats, hamsters, and humans were compared. Summary and Conclusions. Dietary trans-10, cis-12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species. Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids (FA) from adipose tissue and the liver’s inability to sufficiently increase FA oxidation and export of synthesized triglycerides. The pote